Arterial input function calculation in dynamic contrast-enhanced MRI: an in vivo validation study using co-registered contrast-enhanced ultrasound imaging

作者：Mehrabian Hatef^*; Chandrana Chaitanya; Pang Ian; Chopra Rajiv; Martel Anne L

来源：European Radiology, 2012, 22(8): 1735-1747.

DOI：10.1007/s00330-012-2418-1

• Pharmacokinetics
• Independent component analysis (ICA)
• Arterial input AIF)
• Dynamic contrast-enhanced MRI (DCE-MRI)
• Contrast-enhanced ultrasound (CEUS)

Developing a method of separating intravascular contrast agent concentration to measure the arterial input AIF) in dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) of tumours, and validating its performance in phantom and in vivo experiments.
A tissue-mimicking phantom was constructed to model leaky tumour vasculature and DCE-MR images of this phantom were acquired. An in vivo study was performed using tumour-bearing rabbits. Co-registered DCE-MRI and contrast-enhanced ultrasound (CEUS) images were acquired. An independent component analysis (ICA)-based method was developed to separate the intravascular component from DCE-MRI. Results were validated by comparing the time-intensity curves with the actual phantom and in vivo curves.
Phantom study: the AIF extracted using ICA correlated well with the true intravascular curve. In vivo study: the AIFs extracted from DCE-MRI using ICA were very close to the true AIF. Intravascular component images were very similar to the CEUS images. The contrast onset times and initial wash-in slope of the ICA-derived AIF showed good agreement with the CEUS curves.
ICA has the potential to separate the intravascular component from DCE-MRI. This could eliminate the requirement for contrast medium uptake measurements in a major artery and potentially result in more accurate pharmacokinetic parameters.
aEuro cent Tumour response to therapy can be inferred from pharmacokinetic parameters.
aEuro cent Arterial input AIF) is required for pharmacokinetic modelling of tumours.
aEuro cent Independent component analysis has the potential to measure AIF inside the tumour.
aEuro cent AIF measurement is validated using contrast enhanced ultrasound and phantoms.

• 出版日期2012-8