Unilateral Humoral Rejection After Reoperative Single-Lung Transplant

作者:Beaty Claude A; Yang Alexander; George Timothy J; Illei Peter B; Shah Ashish S*
来源:Annals of Thoracic Surgery, 2013, 95(4): E79-E81.
DOI:10.1016/j.athoracsur.2012.09.089

摘要

The role of antibody-mediated rejection in acute and chronic rejection after lung transplantation is poorly understood. We report the case of a prior single-lung transplant recipient undergoing an acute antibody-mediated rejection isolated to her new, contralateral single-lung transplant. A 44-year-old woman 6 years after undergoing a single-lung transplant for idiopathic pulmonary fibrosis underwent a second single-lung transplant for bronchiolitis obliterans syndrome. Despite a negative crossmatch, she subsequently exhibited severe antibody-mediated rejection to her new allograft within 6 days of transplantation. The process of allograft sensitization is dynamic, and further study is warranted to better understand this process.

  • 出版日期2013-4