Association of programmed death ligand-1 (PD-L1) expression with treatment outcomes in patients with BRAF mutation-positive melanoma treated with vemurafenib or cobimetinib combined with vemurafenib

作者：Wongchenko Matthew J.^*; Ribas Antoni; Dreno Brigitte; Ascierto Paolo A.; McArthur Grant A.; Gallo Jorge D.; Rooney Isabelle A.; Hsu Jessie; Koeppen Hartmut; Yan Yibing; Larkin James

来源：Pigment Cell & Melanoma Research, 2018, 31(4): 516-522.

DOI：10.1111/pcmr.12670

• cobimetinib
• immunohistochemistry
• melanoma
• programmed death ligand-1
• prognosis
• vemurafenib

The prognostic significance of programmed death ligand-1 (PD-L1) on treatment outcomes in patients receiving BRAF with or without MEK inhibitors is not well understood. This retrospective exploratory analysis evaluated the association of tumour PD-L1 expression with progression-free survival (PFS) and overall survival (OS) among 210 patients in the coBRIM trial treated with cobimetinib plus vemurafenib or placebo plus vemurafenib. In the vemurafenib cohort, there was a trend of increased PFS and OS in those with PD-L1(+) melanoma, with hazard ratios (HRs; PD-L1(+) vs. PD-L1(-)) of 0.70 (95% CI, 0.46-1.07) and 0.69 (95% CI, 0.42-1.13) for PFS and OS, respectively. However, in patients treated with cobimetinib plus vemurafenib, a similar trend was not observed with HRs (PD-L1(+) versus PD-L1(-)) of 1.04 (95% CI, 0.66-1.68) and 0.94 (95% CI, 0.57-1.57) for PFS and OS, respectively. The combination cobimetinib plus vemurafenib appears to overcome the poor prognosis associated with low PD-L1 expression.

• 出版日期2018-7