Adherence and motility characteristics of clinical Acinetobacter baumannii isolates

作者：Eijkelkamp Bart A; Stroeher Uwe H; Hassan Karl A; Papadimitrious Michael S; Paulsen Ian T; Brown Melissa H^*

来源：FEMS Microbiology Letters, 2011, 323(1): 44-51.

DOI：10.1111/j.1574-6968.2011.02362.x

• twitching
• swarming
• eukaryotic cell adherence
• biofilm formation
• type IV pili
• Australian clinical strains

Acinetobacter baumannii continues to be a major health problem especially in hospital settings. Herein, features that may play a role in persistence and disease potential were investigated in a collection of clinical A. baumannii strains from Australia. Twitching motility was found to be a common trait in A. baumannii international clone I strains and in abundant biofilm formers, whereas swarming motility was only observed in isolates not classified within the international clone lineages. Bioinformatic analysis of the type IV fimbriae revealed a correlation between PilA sequence homology and motility. A high level of variability in adherence to both abiotic surfaces and epithelial cells was found. We report for the first time the motility characteristics of a large number of A. baumannii isolates and present a direct comparison of A. baumannii binding to nasopharyngeal and lung epithelial cells.

• 出版日期2011-10