Mild Traumatic Brain Injury Produces Long-Lasting Deficits in Synaptic Plasticity in the Female Juvenile Hippocampus

作者：White Emily R; Pinar Cristina; Bostrom Crystal A; Meconi Alicia; Christie Brian R

来源：Journal of Neurotrauma, 2017, 34(5): 1111-1123.

DOI：10.1089/neu.2016.4638

• gender
• hippocampus
• long-term potentiation
• mTBI
• synaptic plasticity

Mild traumatic brain injury (mTBI) is becoming recognized as a significant concern in modern society. In particular, youth is being increasingly seen as a vulnerable time period for mTBI, as this is the final developmental period for the brain and typically involves robust synaptic reorganization and axonal myelination. Another issue that is being hotly debated is whether mTBI differentially impacts the male and female brain. To examine the impact of mTBI in the juvenile brain, we measured hippocampal synaptic plasticity using a closed-head mTBI model in male and female Long-Evans rats (25-28 days of age) at either 1h, 1 day, 7 days, or 28 days post-injury. In female rats, the dentate gyrus (DG) region ipsilateral to the impact showed a significant reduction in long-term potentiation (LTP) at 1 day, which persisted to 28 days following injury. In male rats, the deficit in LTP was maximal in the CA1 and DG subfields ipsilateral to the impact site 7 days post-injury; however, these deficits did not persist to 28 days post-injury. These data indicate that mTBI can produce more immediate and persistent impairments in synaptic plasticity in the female brain.

• 出版日期2017-3-1