Accurate Prediction of the Stage of Histological Chorioamnionitis before Delivery by Amniotic Fluid IL-8 Level

作者：Yoneda Satoshi; Shiozaki Arihiro; Ito Mika; Yoneda Noriko; Inada Kumiko; Yonezawa Rika; Kigawa Mika; Saito Shigeru^*

来源：American Journal of Reproductive Immunology, 2015, 73(6): 568-576.

DOI：10.1111/aji.12360

• Amniotic fluid
• body temperature
• histological chorioamnionitis
• interleukin-8
• preterm labor

ObjectiveTo estimate the stage of histological chorioamnionitis (h-CAM) antenatally using clinical data.
Materials and methodsFour hundred and twenty-eight singleton mothers were recruited. Clinical data including the levels of white blood cell count (WBC), C-reactive protein (CRP), amniotic fluid interleukin-8 (AF-IL-8) at Cesarean section, and maternal body temperature (MBT) were collected.
ResultsHistological chorioamnionitis was present in 45.3% of the cases. Poor neonatal prognosis was highest (59.1%) in cases with h-CAM stage III. AF-IL-8 (odds ratio: 8.5, 95% CI: 5.1-14.8, P<0.0001) and MBT (odds ratio: 2.3, 95% CI: 1.13-4.1, P=0.0192) were independent risk factors for h-CAM. The cutoff value of AF-IL-8 for predicting each stage of h-CAM (stage I or higher, stage II or higher, and stage III) were 9.9ng/mL, 17.3ng/mL, and 55.9ng/mL, respectively.
ConclusionThe stage of h-CAM was able to be predicted accurately by the level of AF-IL-8 before delivery.

• 出版日期2015-6