Association of the Plasminogen Activator Inhibitor-1 (PAI-1) Gene-675 4G/5G and-844 A/G Promoter Polymorphism with Risk of Keloid in a Chinese Han Population

作者：Wang, Yongjie; Long, Jianhong^*; Wang, Xiaoyan; Sun, Yang

来源：MEDICAL SCIENCE MONITOR, 2014, 20: 2069-2073.

DOI：10.12659/MSM.892397

• Keloid
• Plasminogen Activator Inhibitor 1
• Polymorphism, Single Nucleotide

Background: A keloid is pathological scar caused by aberrant response to skin injuries, characterized by excessive accumulation of histological extracellular matrix, and occurs in genetically susceptible individuals. Plasminogen activator inhibitor-1 (PAI-1) has been implicated in the pathogenesis of keloid. We investigated the association between PAI-1 polymorphisms and plasma PAI-1 level with keloid risk.
Material/Methods: A total of 242 Chinese keloid patients and 207 controls were enrolled in this study. Polymerase chain reaction-restriction technique was used to determine PAI-1 promoter polymorphism (-675 4G/5G and -844 A/G) distribution. Plasma PAI-1 levels were detected using enzyme-linked immunosorbent assay (ELISA).
Results: There was a statistically significant difference in the distribution of PAI-1 -675 4G/5G polymorphism between keloid patients and healthy controls. 4G/4G carriers were more likely to develop keloid. In contrast, the -844 A/G polymorphism distribution did not vary significantly between keloid patients and controls. The keloid patients group had a significantly higher plasma PAI-1 level than the control group. In the -675 4G/4G carrier population, the plasma PAI-1 levels were significant higher in keloid patients compared with controls.
Conclusions: Our study provides evidence that PAI-1 promoter polymorphism -675 4G/5G and plasma PAI-1 level are associated with keloid risk. PAI-1 -675 4G/5G polymorphism may be an important hereditary factor responsible for keloid development in the Chinese Han population.

• 出版日期2014-10-28
• 单位中南大学