Design and synthesis of immobilized Tamiflu analog on resin for affinity chromatography

作者：Kimura Yasuaki; Yamatsugu Kenzo; Kanai Motomu^*; Echigo Noriko; Kuzuhara Takashi; Shibasaki Masakatsu

来源：Tetrahedron Letters, 2009, 50(26): 3205-3208.

DOI：10.1016/j.tetlet.2009.01.142

• Tamiflu
• Immobilization
• Affinity chromatography
• Abnormal behavior
• Neuraminidase

A resin linked with the Tamiflu core was synthesized by modifying our original synthetic route Of oseltamivir phosphate (Tamiflu). The prepared resin bound to the influenza virus enzyme neuraminidase, the main target of Tamiflu. The immobilized Tamiflu analog will be useful for isolating and identifying presumed endogenous vertebrate proteins that interact with Tamiflu, which might relate to the abnormal behavior exhibited by some influenza patients treated with Tamiflu.

• 出版日期2009-7-1