A Fully Integrated 8-Channel Closed-Loop Neural-Prosthetic CMOS SoC for Real-Time Epileptic Seizure Control

作者：Chen Wei Ming^*; Chiueh Herming; Chen Tsan Jieh; Ho Chia Lun; Jeng Chi; Ker Ming Dou; Lin Chun Yu; Huang Ya Chun; Chou Chia Wei; Fan Tsun Yuan; Cheng Ming Seng; Hsin Yue Loong; Liang Sheng Fu; Wang Yu Lin; Shaw Fu Zen; Huang Yu Hsing; Yang Chia Hsiang; Wu Chung Yu

来源：IEEE Journal of Solid-State Circuits, 2014, 49(1): 232-247.

DOI：10.1109/JSSC.2013.2284346

• Closed-loop control
• epilepsy
• neuron modulation
• neural prosthesis
• system-on-Chip (SoC)
• wireless power transmission

An 8-channel closed-loop neural-prosthetic SoC is presented for real-time intracranial EEG (iEEG) acquisition, seizure detection, and electrical stimulation in order to suppress epileptic seizures. The SoC is composed of eight energy-efficient analog front-end amplifiers (AFEAs), a 10-b delta-modulated SAR ADC (DMSAR ADC), a configurable bio-signal processor (BSP), and an adaptive high-voltage-tolerant stimulator. A wire-less power-and-data transmission system is also embedded. By leveraging T-connected pseudo-resistors, the high-pass (low-pass) cutoff frequency of the AFEAs can be adjusted from 0.1 to 10 Hz (0.8 to 7 kHz). The noise-efficiency factor (NEF) of the AFEA is 1.77, and the DMSAR ADC achieves an ENOB of 9.57 bits. The BSP extracts the epileptic features from time-domain entropy and frequency spectrum for seizure detection. A constant 30-mu A stimulus current is delivered by closed-loop control. The acquired signals are transmitted with on-off keying (OOK) modulation at 4 Mbps over the MedRadio band for monitoring. A multi-LDO topology is adopted to mitigate the interferences across different power domains. The proposed SoC is fabricated in 0.18-mu m CMOS and occupies 13.47 mm(2). Verified on Long Evans rats, the proposed SoC dissipates 2.8 mW and achieves high detection accuracy 92% within 0.8 s.

• 出版日期2014-1
• 单位河北医科大学