Hereditary Thrombophilic Factors in Glaucoma

作者：Sekeroglu Mehmet A^*; Irkec Murat; Mocan Mehmet C; Orhan Mehmet

来源：Journal of Glaucoma, 2016, 25(2): 203-207.

DOI：10.1097/IJG.0000000000000148

• exfoliation
• glaucoma
• homocysteine
• thrombosis

Purpose: To evaluate the hereditary thrombophilic factors in patients with primary open-angle glaucoma, exfoliative glaucoma, and exfoliation syndrome and to compare their results with those of healthy control subjects.
Materials and Methods: The study included 75 patients [25 patients with primary open-angle glaucoma (group I), 25 patients with exfoliative glaucoma (group II), and 25 patients with exfoliation syndrome (group III)] and 25 healthy control subjects (group IV). Well-known hereditary thrombophilic factors including methylenetetrahydrofolate reductase (MTHFR) gene C677T mutation, prothrombin G20210A mutation, factor V Leiden mutation, activated protein C resistance, protein S, protein C, and antithrombin III activities, and homocysteine levels were measured in venous blood samples of all subjects.
Results: Fifty-one males and 49 females were included in the study. The mean age of the patients was 67.8 +/- 8.7 years (range, 46 to 87 y). There was no statistically significant difference with regard to the mean age (P = 0.057) and distribution of sex (P = 0.391) between the study groups. The difference of homocysteine, folate, vitamin B-12, antithrombin III activity, protein C activity, free protein S activity, and activated protein C resistance were not statistically significant; and the number of subjects with MTHFR C677T, prothrombin G20210A, and factor V Leiden mutations were similar between the study groups.
Conclusion: Our results suggest that there is no significant difference between the prothrombotic inherited risk factors of glaucomatous and nonglaucomatous subjects.

• 出版日期2016-2