Al(OTf)(3): an efficient recyclable catalyst for direct nucleophilic substitution of the hydroxy group of propargylic alcohols with carbon- and heteroatom-centered nucleophiles to construct C-C, C-O, C-N and C-S bonds

作者：Gohain Mukut; Marais Charlene; Bezuidenhoudt Barend C B^*

来源：Tetrahedron Letters, 2012, 53(9): 1048-1050.

DOI：10.1016/j.tetlet.2011.12.060

• Aluminum triflate
• Propargylic alcohols
• Nucleophiles
• Regioselectivity

A general and highly efficient Al(OTf)(3)-catalyzed methodology has been developed for the direct nucleophilic substitution of the hydroxy group in propargylic alcohols with a variety of carbon- and heteroatom-centered nucleophiles such as alcohols, aromatic compounds, amides, and thiols, leading to the construction of C-C, C-O, C-N and C-S bonds.

• 出版日期2012-2-29