科研之友
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摘要
In this review, we first analyzed the current status of cholinergic anti-inflammatory pathway and then put forward a novel regulatory machinery-pulmonary parasympathetic inflammatory reflex, which is composed by lung vagal sensors at afferent arm, alpha 7 nAChR (alpha 7 nicotinic acetylcholine receptors)-expressing cells at efferent arm and the brain information integrating center. This modulatory circuit might loop the lungs, immune and nervous systems and play a very important role in regulating lung infection, inflammation and immunity through the neural innervations and signals when the lungs encounter pathogenic challenges.
- 出版日期2014-10
- 单位中国科学院上海巴斯德研究所
