Arachidonic acid omega-hydroxylase CYP4A11: inter-ethnic variations in the 8590T %26gt; C loss-of-function variant

作者：Cardenas Christian Lacks Lino; Devos Aurore; Toure Aminata; Garcia Jaime Cardenas; Kenani Abderraouf; Migot Nabias Florence; Broly Franck; Chevalier Dany^*

来源：Molecular Biology Reports, 2012, 39(2): 1503-1508.

DOI：10.1007/s11033-011-0888-x

• Cytochrome P450
• Arachidonic acid
• CYP4A11
• 20-Hydroxyeicosatetraenoic acid
• Genetic polymorphisms
• Inter-ethnic variations

The human Cytochrome P450 4A11 (CYP4A11) is a major omega-hydroxylase involved in the regulation of blood pressure in the kidney through the conversion of arachidonic acid into 20-hydroxyeicosatetraenoic acid (20-HETE). Previous studies have reported a significant association between the 8590T %26gt; C genetic variant of CYP4A11 and hypertension. Interestingly, several population-based studies have reported ethnic differences in the prevalence of hypertension, with the highest prevalence in African populations. The aim of this work was to determine the frequency and inter-ethnic comparison of the CYP4A11 (8590T %26gt; C) functional polymorphism, in five new ethnic groups: European (99 French Caucasians), African (36 Gabonese and 50 Senegalese), South American (60 Peruvians) and North African (53 Tunisians) populations, using polymerase chain reaction-single strand conformational polymorphism and sequencing strategies. We confirmed that the CYP4A11 (8590T %26gt; C) functional polymorphism exhibits inter-ethnic frequency differences. Noteworthy, the highest 8590C allele frequency was observed in the Tunisian (30.2%), followed by Senegalese (20%) populations. In addition, the CC genotype was only found in the Gabonese and Tunisian populations (5.6% and 8.4%, respectively). These populations may be of major interest to help to clarify the linkage between hypertension and CYP4A11 (8590T %26gt; C) genotype in African populations. These findings provide data for further studies that investigate the potential association of CYP4A11 (8590T %26gt; C) variant with an incidence of hypertension genesis in respect of ethnicity.

• 出版日期2012-2