NMDA and GABA receptor presence in rat heart mitochondria

作者：Nesterov Semen V; Skorobogatova Yulia A; Panteleeva Alisa A; Pavlik Lyubov L; Mikheeva Irina B; Yaguzhinsky Lev S; Nartsissov Yaroslav R^*

来源：Chemico-Biological Interactions, 2018, 291: 40-46.

DOI：10.1016/j.cbi.2018.06.004

• Mitochondria
• NMDA receptor
• GABA receptor
• Heart metabolism

The purpose of this study is to demonstrate the presence of three more receptors in mitochondria. Two N-methyl-D-aspartate receptor (NMDAR) subunits (NR1 and NR2B) are found by protein immunoblot and immunogold labeling in mitochondria fraction isolated from rat heart. These data allow supposing NMDAR presence and functioning in the inner mitochondrial membrane. There are no signs of receptor presence obtained in heart tissue lysate, that indicates the receptor localization exactly in mitochondria. The possible receptor functions discussed are its participation in calcium transport and in excitation-metabolism coupling. Besides, preliminary evidence is obtained of GABA(A) and GABA(B) receptors presence in heart mitochondria. One can surmise their role in metabolism regulation and their possible co-operation with NMDAR just as in the nervous system.

• 出版日期2018-8-1