Anti-HBs positive occult hepatitis B virus carrier blood infectious in two transfusion recipients

作者：Levicnik Stezinar Snezna^*; Rahne Potokar Urska; Candotti Daniel; Lelie Nico; Allain Jean Pierre

来源：Journal of Hepatology, 2008, 48(6): 1022-1025.

DOI：10.1016/j.jhep.2008.02.016

• HBV
• occult HBV
• infectivity
• blood transfusion

Background/Aims: Occult hepatitis B infection (OBI) in blood donations is not considered infectious when anti-HBs is present.
Methods: Four months after transfusion of eight blood components during coronary arterial bypass surgery, a 59-year-old patient developed acute hepatitis B. A second 71-year-old patient transfused with a red cell concentrate (RCC) from one of these donations had early HBV infection 7 months post-transfusion. Samples were tested for HBV serological markers and HBV DNA was quantified and sequenced.
Results: One implicated donation contained anti-HBc, anti-HBs (12 IU/L) and 180 IU/ml of HBV DNA. Previous and subsequent samples contained 3-10 times lower viral load and slightly variable anti-HBs. Two previous donations did not cause HBV infection. Recipients of the FFP and RCC from the index donation were both HBV infected and carried genotype D strains with sequences identical to the donor strain.
Conclusions: Despite anti-HBs, an OBI carrier transmitted HBV to two immunocompetent transfusion recipients.

• 出版日期2008-6