A single nucleotide polymorphism of IL-17 gene in the recipient is associated with acute GVHD after HLA-matched unrelated BMT

作者：Espinoza J L; Takami A^*; Onizuka M; Kawase T; Sao H; Akiyama H; Miyamura K; Okamoto S; Inoue M; Ohtake S; Fukuda T; Morishima Y; Kodera Y; Nakao S

来源：Bone Marrow Transplantation, 2011, 46(11): 1455-1463.

DOI：10.1038/bmt.2010.325

• IL-17
• unrelated donor
• single-nucleotide polymorphism

IL-17 has an important role in the host defense against extracellular pathogens and the pathophysiology of autoimmune diseases. This study retrospectively examined the impact of a single-nucleotide polymorphism (rs2275913, G197A) in the IL-17 gene of a total 510 recipients with hematologic malignancies and their unrelated donors on the clinical outcomes in HLA-matched myeloablative (discovery study) and nonmyeloablative (validation study) BMT through the Japan Marrow Donor Program (JMDP). In the discovery study, the presence of a 197A genotype in the recipient resulted in a higher incidence of grades II-IV acute GVHD (hazard ratio (HR), 1.87; 95% confidence interval (CI), 1.23-2.85; P = 0.004). The donor IL-17A genotype did not significantly influence the transplant outcomes. The validation study showed a trend toward an association of the recipient 197A genotype with an increased risk of grades III-IV acute GVHD (HR, 5.84; 95% CI, 0.75-45.72; P = 0.09), as well as a significantly increased risk for chronic GVHD (HR, 3.86; 95% CI, 1.29-11.59; P = 0.02). These results suggest an association of the 197A genotype in the recipient side with the development of acute GVHD. Bone Marrow Transplantation (2011) 46, 1455-1463; doi:10.1038/bmt.2010.325; published online 10 January 2011

• 出版日期2011-11