Action initiation shapes mesolimbic dopamine encoding of future rewards

作者：Syed Emilie C J; Grima Laura L; Magill Peter J; Bogacz Rafal; Brown Peter; Walton Mark E^*

来源：Nature Neuroscience, 2016, 19(1): 34-+.

DOI：10.1038/nn.4187

It is widely held that dopamine signaling encodes predictions of future rewards and such predictions are regularly used to drive behavior, but the relationship between these two is poorly defined. We found in rats that nucleus accumbens dopamine following a reward-predicting cue was attenuated unless movement was correctly initiated. Our results indicate that dopamine release in this region is contingent on correct action initiation and not just reward prediction.

• 出版日期2016-1