Diversity-oriented, one-pot, multi-component synthesis of substituted uracil derivatives

作者：Pedgaonkar Yogesh Y; Degani Mariam S^*; Iyer Radhakrishnan P

来源：Molecular Diversity, 2011, 15(1): 263-267.

DOI：10.1007/s11030-010-9266-1

• Multicomponent reaction
• Carbonylation
• Cyclization
• 5-cyanouracil
• Triphosgene
• MCR

With the emergence of high throughput screening of bioactive molecules, there is constant need for the development of new strategies for diversity-oriented synthesis. We describe here a novel one-pot multicomponent reaction for the synthesis of uracil derivatives using easily available starting materials. This new synthetic strategy provides easy access to diverse uracil derivatives in moderate to good yields.

• 出版日期2011-2