A New Method of Discrimination for Peaks of Enantiopure Compounds in Chiral Separation of HPLC

作者：He Zhi Jian; Zhang Yi Wen; Ya Shun; Tu Bin; Song Hang^*

来源：Asian Journal of Chemistry, 2013, 25(8): 4351-4355.

• High performance liquid chromatography
• Diode array detector
• Chiral Separation
• Enantiomer
• Diastereomer
• Isomer

Diode array detector is one of the most popular detectors of high performance liquid chromatography (HPLC). With the full-band scanning, it has been used extensively for the qualitative and quantitative analysis of components. In this paper, a few groups of enantiomers diastereomers, isomers and homologue Were chosen as analytes and a new method of discrimination for their peaks in chromatogram of; was tried to be developed. By using diode array detector, we obtained peak characteristics for them. By comparing chromatograms Of enantiomers, diastereomers, isomers and homologue, We find that only the chromatograms Of the,enantiomers and diastereomers have considerable consistency Then, a new method of discrimination for peaks of enantiopure compounds by diode array detector has been established. This method can be used for research of chiral separation

• 出版日期2013-7
• 单位绵阳师范学院; 四川大学