Acetic Acid Enhanced Narrow Band Imaging for the Diagnosis of Gastric Intestinal Metaplasia

作者：Sha, Jie; Wang, Pin; Zhu, Bingliang; Zhu, Minghui; Li, Xueliang^*; Gao, Feng^*

来源：PLos One, 2017, 12(1): e0170957.

DOI：10.1371/journal.pone.0170957

• MAGNIFICATION CHROMOENDOSCOPY
• MAGNIFYING ENDOSCOPY
• CANCER
• LESIONS
• EPIDEMIOLOGY
• SURVEILLANCE
• PREVENTION
• ESOPHAGUS
• DYSPLASIA
• RISK

Gastric intestinal metaplasia (GIM) is a precancerous lesion of the stomach. The detection of GIM using conventional white-light endoscopy (WLE) is difficult. In this study, we determined whether acetic acid-enhanced narrow band imaging (AA-NBI) improves the detection of GIM. A consecutive cohort of 132 individuals aged 40 years or older was subjected to upper gastrointestinal endoscopy using WLE, NBI and AA-NBI. The ability of the three methods to diagnose GIM in patients was compared. Histological assessment (per-patient and per-biopsy) was used for the accuracy assessment. Sixty-six (50.0%) out of the 132 individuals examined were found to have GIM, of which 44 (66.7%) were diagnosed correctly by NBI (sensitivity 66.7% and specificity 68.2%) and 58 (87.9%) were correctly identified by AA-NBI (sensitivity 87.9% and specificity 68.2%), as compared to only 22 (33.3%) by WLE (sensitivity 33.3% and specificity 28.8%). Therefore, the sensitivity of AA-NBI in the diagnosis of GIM was significantly higher than NBI (p<0.05) and WLE (p<0.001). Our study indicates that AA-NBI can improve the accuracy of endoscopy-targeted biopsies for GIM.

• 出版日期2017-1-30
• 单位南京医科大学