Antihypercholesterolemic Effects of Fruit Aqueous Extract of Copernicia prunifera (Miller)H. E. Moore in Mice Diet-Induced Hypercholesterolemia

作者：Terceiro Paim Raquel Teixeira; Benjamin Stephen Rathinaraj; Rondina Davide; Mendes Marques Marcia Maria; Viana Daniel de Araujo; da Costa Gonzaga Maria Leonia; Pinto Vieira Icaro Gusmao; Pereira Mendes Francisca Noelia; Florindo Guedes Maria Izabel

来源：Evidence-Based Complementary and Alternative Medicine, 2017, 2017: 6376173.

DOI：10.1155/2017/6376173

The present objective of the investigation is to evaluate the antihypercholesterolemic activity of the aqueous fruit pulp extract (APE) of Copernicia prunifera (Miller) H. E. Moore (Arecaceae family). Various chemical characterization methods like thin layer chromatography, Fourier transform infrared spectroscopy, H-1 and C-13 NMR, and molecular weight by gel permeation chromatography have been employed to characterize the extracted pectin. The present study demonstrated that hypercholesterolemic diet (HD) created hypercholesterolemia, caused significant increases in body weight, total cholesterol, and low-density lipoprotein, and caused decreases in high-density lipoprotein in serum compared with SD group. Two doses (APE 150 and 300mg/Kg b.w./day) were administered to hyperlipidemic mice for 90 days. APE reversed body weight changes, changed serumlipids to normal values, and significantly inhibited the changes of lipid peroxidation and inflammation in the liver tissues. The renal parameters analyzed (urea and creatinine) altered by diet were reverted to normal values. Our results revealed that aqueous fruit pulp extracts of carnauba reduced hypercholesterolemia showing a potential preventive effect against cardiovascular diseases without side effects cause.

• 出版日期2017