Adverse Reactions of Atazanavir, Fosamprenavir and Tipranavir in "Real Life".

作者：Balayssac Eric^*; Autret Leca Elisabeth; Jonville Bera Annie Pierre; Die Kacou Henri; Beau Salinas Frederique

来源：Therapie, 2010, 65(2): 121-128.

DOI：10.2515/therapie/2010003

• antiretroviral drugs
• adverse effects
• spontaneous reporting
• pharmacovigilance

Adverse Reactions of Atazanavir, Fosamprenavir and Tipranavir in "Real Life". Objective. To precise adverse effects of atazanavir, fosamprenavir and tipranavir "in real life".
Method. Descriptive study of 3 protease inhibitor adverse effects stored in the French Bank of Pharmacovigilance.
Results. Nineteen adverse effects having at least possible links with antiretroviral drugs studied were reported. It was essentially hepatobiliary (atazanavir: 29/59, tipranavir: 4/6) and skin (fosamprenavir: 10/20) adverse reactions. These reactions, relatively "serious" (35.1%) led to the interruption of the person (or persons) medication (s) suspected ( s) in 69 folders (82.1%) and evolved to healing without sequelae in 68 folders (81%).
Conclusion. The drug side effects were for the most expected. However, their frequency and their seriously underline the interest of a post-AMM monitoring to reassess the drugs risk-benefit report.

• 出版日期2010-4