Application of Mosher's method for absolute configuration assignment to bioactive plants and fungi metabolites

作者：Cimmino Alessio; Masi Marco; Evidente Marco; Superchi Stefano^*; Evidente Antonio^*

来源：Journal of Pharmaceutical and Biomedical Analysis, 2017, 144: 59-89.

DOI：10.1016/j.jpba.2017.02.037

• Plant and fungi metabolites
• Chiral natural products
• Absolute configuration
• Advanced Mosher's method
• Biological activity

The review deals with the application of the NMR advanced Mosher's method for the assignment of the absolute configuration to plant and fungal metabolites belonging to different classes of natural compounds. The structural and stereochemical characterization of these naturally occurring metabolites, as well as their biological properties as possible drugs or agrochemicals is reviewed. The importance of the absolute and relative stereochemistry on their biological properties is also highlighted. Successes and failures of application of the advanced Mosher's method are reported.

• 出版日期2017-9-10