Novel Natural Products for Healthy Ageing from the Mediterranean Diet and Food Plants of Other Global SourcesThe MediHealth Project

作者：Waltenberger Birgit; Halabalaki Maria; Schwaiger Stefan; Adamopoulos Nicolas; Allouche Noureddine; Fiebich Bernd L; Hermans Nina; Jansen Duerr Pidder; Kesternich Victor; Pieters Luc; Schoenbichler Stefan; Skaltsounis Alexios Leandros; Tran Hung; Trougakos Ioannis P; Viljoen Alvaro; Wolfender Jean Luc; Wolfrum Christian; Xynos Nikos; Stuppner Hermann

来源：Molecules, 2018, 23(5): 1097.

DOI：10.3390/molecules23051097

• MediHealth
• healthy ageing
• Mediterranean diet
• food plants
• natural products
• metabolites
• bioavailability
• pharmacology
• phytochemistry
• synthetic chemistry

There is a rapid increase in the percentage of elderly people in Europe. Consequently, the prevalence of age-related diseases will also significantly increase. Therefore, the main goal of MediHealth, an international research project, is to introduce a novel approach for the discovery of active agents of food plants from the Mediterranean diet and other global sources that promote healthy ageing. To achieve this goal, a series of plants from the Mediterranean diet and food plants from other origins are carefully selected and subjected to in silico, cell-based, in vivo (fly and mouse models), and metabolism analyses. Advanced analytical techniques complement the bio-evaluation process for the efficient isolation and identification of the bioactive plant constituents. Furthermore, pharmacological profiling of bioactive natural products, as well as the identification and synthesis of their metabolites, is carried out. Finally, optimization studies are performed in order to proceed to the development of innovative nutraceuticals, dietary supplements or herbal medicinal products. The project is based on an exchange of researchers between nine universities and four companies from European and non-European countries, exploiting the existing complementary multidisciplinary expertise. Herein, the unique and novel approach of this interdisciplinary project is presented.

• 出版日期2018-5