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摘要
The atypical antipsychotic treatment is associated with weight gain and alteration of glucose and lipid metabolism. The effects of aripiprazole which is a third generation antipsychotic drug associated with reduced weight gain, were investigated on adipose tissue. The triglyceride content of adipose tissue along with adipocyte's lipid droplet size was determined. The experiments were performed using adult, female Wistar rats, divided in 3 groups as follows: Control group (n = 8) -vehicle, aripiprazole 4 mg kg(-1) b.wt. (n = 8) and aripiprazole 8 mg kg(-1) b.wt. (n = 8). The drugs were administered orally twice daily for 32 days. Samples were taken from perirenal area, triglyceride content of cells was determined using colorimetric enzymatic method. Histological evaluation of the perirenal adipose tissue was performed by morphological characterization of adipocytes. The triglyceride content of adipocytes was significantly lower in the aripiprazole treated groups than in control (p<0.001). The triglyceride level lowering effect was not dose dependent, the difference between the two treated groups was not statistically significant (p>0.05). Evaluating the lipid droplet size distribution, we found significant difference between control and treated groups (p<0.001). The aripiprazole treatment caused a marked decrease in lipid droplet size. The morphological evaluation confirmed an increased presence of multivacuolar fat cells. The decrease in triglyceride content of adipose tissue associated with increased multivacuolar cell presence could suggest that aripiprazole treatment may increase the preadipocyte proliferation.
- 出版日期2013-5-15
