Scanning tunneling spectrosopy study of DNA conductivity

作者:Kratochvilova Irena*; Kral Karel; Buncek Martin; Nespurek Stanislav; Todorciuc Tatiana; Weiter Martin; Navratil Jiri; Schneider Bohdan; Pavluch Jiri
来源:Central European Journal of Physics, 2008, 6(3): 422-426.
DOI:10.2478/s11534-008-0072-7

摘要

We used STM to study the conductivity of 32 nucleotide long DNA molecules chemically attached to a gold surface. Two oligonucleotides containing all four base types namely G, A, C, T, one single stranded and one double helical, all showed conductance data significantly higher than DNA containing only T and A that were either single stranded d(T32) or double helical d(T32).d(A32) in confirmation. Within each sequence group, the conductivity of the double helical form was always higher than that of the single strand. We discuss the impact of structure, particular base stacking and affinity to the phase transition.

  • 出版日期2008-9