A new approach to the enantioseparation of Betti bases

作者：Alfonsov Vladimir A^*; Metlushka Kirill E; McKenna Charles E; Kashemirov Boris A; Kataeva Olga N; Zheltukhin Viktor F; Sadkova Dilyara N; Dobrynin Alexey B

来源：Synlett, 2007, (3): 488-490.

DOI：10.1055/s-2007-967941

• enantioseparation
• 1-(alpha-aminobenzyl)-2-naphthols
• 1,3-diaryl-2,3-dihydro-1H-naphth[1,2-e][1,3]oxazine
• tartaric acid

An improved method for enantioseparation of racemic 1-(alpha-aminobenzyl)-2-naphthols has been developed by the reaction in situ of Betti base product mixtures with L-(+)-tartaric acid taken in a 1:1 ratio. The products of this reaction are (-)-1-(alpha-aminobenzyl)-2-naphthol tartrate, the acetal of benzaldehyde and tartaric acid as well as (+)-1,3-diaryl-2,3-dihydro-1H-naphth[1,2-e][1,3]oxazine, which can be easily separated by crystallization.

• 出版日期2007-2-15