A Study to Draw a Normative Database of Laryngopharynx pH Profile in Chinese

作者：Feng Guijian^*; Wang Junyao; Zhang Lihong; Liu Yulan

来源：Journal of Neurogastroenterology and Motility, 2014, 20(3): 347-351.

DOI：10.5056/jnm13138

• Esophageal pH monitoring
• Gastroesophageal reflux
• Laryngopharyngeal reflux

Background/Aims
To draw a normative database of laryngopharynx pH profile in Chinese subjects.
Methods
Normal volunteers were recruited from "www.Ganji.com" and People's hospital between May 2008 and December 2009. The Restech pH Probes were calibrated in pH 7 and pH 4 buffer solutions according to the manufacturer's instructions. Each volunteer was asked to wear the device for a 24-hour period and was encouraged to participate in normal daily activities.
Results
The healthy volunteers consisted of 20 males and 9 females with a median age of 23 years (interquartile range, 21 to 32 years). The 95th percentiles for % total times at pH < 4, pH < 4.5, pH < 5.0 and pH < 5.5 for the oropharynx pH catheter were 0.06%, 1.01%, 7.23% and 27.34%, respectively. The 95th percentile for number of reflux events within the 24-hour period at pH < 4, pH < 4.5, pH < 5.0 and pH < 5.5 were 2.0, 18.0, 107.5 and 284.5, respectively.
Conclusions
This is the first study to systematically assess the degree of reflux detected by the new pH probe in healthy asymptomatic Chinese volunteers and to report normative values in Chinese people. Using an oropharyngeal pH catheter to monitor laryngopharyngeal reflux indicated that in healthy Chinese, reflux should be considered normal if the percent time at pH less than 4.5 is no more than 1%.

• 出版日期2014-7
• 单位北京大学