Adiponectin is associated with dynamic hyperinflation and a favourable response to inhaled glucocorticoids in patients with COPD

作者：Leivo Korpela Sirpa^*; Lehtimaki Lauri; Vuolteenaho Katriina; Nieminen Riina; Koobi Lea; Jarvenpaa Ritva; Kankaanranta Hannu; Saarelainen Seppo; Moilanen Eeva

来源：Respiratory Medicine, 2014, 108(1): 122-128.

DOI：10.1016/j.rmed.2013.08.016

• Adipokines
• Adiponectin
• Leptin
• Chronic obstructive pulmonary disease (COPD)
• Pulmonary emphysema
• Glucocorticoid

Objectives: Adipokines are protein mediators first described as products of adipose tissue regulating energy metabolism and appetite. Recently, adipokines have also been found to modulate inflammation and smooth muscle cell responses. Therefore we investigated the association of two adipokines, adiponectin and leptin, with the degree of emphysema, pulmonary function, symptoms and glucocorticoid responsiveness in patients with COPD. %26lt;br%26gt;Methods: Plasma adiponectin and leptin levels, spirometry, body plethysmography and symptoms were measured in 43 male COPD patients with smoking history %26gt;= 20 pack-years, post bronchodilator FEV1/FVC %26lt; 0.7 and pulmonary emphysema on HRCT. The measurements were repeated in a subgroup of patients after 4 weeks%26apos; treatment with inhaled fluticasone. %26lt;br%26gt;Results: In patients with COPD, plasma adiponectin levels correlated positively with airway resistance (Raw) (r = 0.362, p = 0.019) and functional residual capacity (FRC) (r = 0.355, p = 0.046). Furthermore, the baseline adiponectin concentration correlated negatively with the fluticasone induced changes in St George%26apos;s Respiratory questionnaire (SGRQ) symptom score (r = -0.413, p = 0.040) and in FRC % pred (r = -0.428, p = 0.003), i.e. a higher baseline plasma adiponectin level was associated with more pronounced alleviation of symptoms and dynamic hyperinflation. Plasma leptin levels were not related to the measures of lung function, symptoms or glucocorticoid responsiveness. %26lt;br%26gt;Conclusions: Plasma adiponectin levels were associated with peripheral airway obstruction and dynamic hyperinflation in patients with COPD. A higher adiponectin level predicted more favourable relief of symptoms and hyperinflation during glucocorticoid treatment. Adiponectin may have a role in the COPD pathogenesis; it may also be a biomarker of disease severity and treatment responses in this disease.

• 出版日期2014-1