A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice

作者：Roberts Megan N; Wallace Marita A; Tomilov Alexey A; Zhou Zeyu; Marcotte George R; Tran Dianna; Perez Gabriella; Gutierrez Casado Elena; Koike Shinichiro; Knotts Trina A; Imai Denise M; Griffey Stephen M; Kim Kyoungmi; Hagopian Kevork; Haj Fawaz G; Baar Keith; Cortopassi Gino A; Ramsey Jon J^*; Alberto Lopez Dominguez Jose

来源：Cell Metabolism, 2017, 26(3): 539-+.

DOI：10.1016/j.cmet.2017.08.005

Calorie restriction, without malnutrition, has been shown to increase lifespan and is associated with a shift away from glycolysis toward beta-oxidation. The objective of this study was to mimic this metabolic shift using low-carbohydrate diets and to determine the influence of these diets on longevity and healthspan in mice. C57BL/6 mice were assigned to a ketogenic, low-carbohydrate, or control diet at 12 months of age and were either allowed to live their natural lifespan or tested for physiological function after 1 or 14 months of dietary intervention. The ketogenic diet (KD) significantly increased median lifespan and survival compared to controls. In aged mice, only those consuming a KD displayed preservation of physiological function. The KD increased protein acetylation levels and regulated mTORC1 signaling in a tissue-dependent manner. This study demonstrates that a KD extends longevity and healthspan in mice.

• 出版日期2017-9-5