科研之友
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摘要
Synthesis of alpha-amino-alpha'-hydroxyphosphinates has been achieved through hydrophosphinylation of alpha-amino-H-phosphinates to aldehydes with highly retentive phosphorus chirality. Treatment of alpha-substituted a-amino-H-phosphinates with aldehydes in the presence of magnesium oxide without solvent gave alpha-amino-alpha'hydroxyphosphinates. The reaction proceeded with 80-94% retention of configuration at the phosphorus atom.
- 出版日期2007-10-16
