Molecular epidemiology of rotavirus infections among children hospitalized for acute gastroenteritis in Shanghai, China, 2001 through 2005

作者：Xu, Jin^*; Yang, Yi; Sun, Jiae; Ding, Yunzhen; Su, Liyun; Fang, Zhaoyin; Glass, Roger I.

来源：Journal of Clinical Virology, 2009, 44(1): 58-61.

DOI：10.1016/j.jcv.2008.09.012

• Rotavirus
• Gastroenteritis
• Genotype
• Children

Background: Rotavirus is the most common Cause of severe diarrhea in children in the world. Knowing the prevalence and genotypes of these infections is important for implementing vaccination programs. @@@ Objectives: To determine the prevalence and genotypes of rotavirus infections in Shanghai, China between 2001 and 2005. @@@ Study design: Stool specimens were analyzed from children under 5 years old who were hospitalized for acute gastroenteritis. @@@ Results: 0175411 specimens, 1436(26.5%) were rotavirus-positive. More than 80% of children with rotavirus infections were younger than 2 years old. Prevalence peaked from October to December each year. The G3, P[8], and P[8]G3 genotypes were the most common during these 5 years. The prevalence of the G I genotype decreased from 29% in 2001 to 2% in 2004. @@@ Conclusions: In Shanghai, use of currently available vaccines against rotaviruses would be effective, especially for infants less than 2 years old. Information on the variations of circulating genotypes in this area of China provides useful data for formulating vaccine policy and evaluating vaccine efficacy.

• 出版日期2009-1
• 单位中国疾病预防控制中心病毒病预防控制所; 复旦大学; 中国疾病预防控制中心