科研之友
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摘要
A library of heterocyclic products with a wide variety of organic residues is produced via a four-component reaction of alpha,beta-unsaturated aldehydes, primary amines, carbon monoxide, and ethylene using a multi-reactor station with an array of 96 autoclaves employing the same high-pressure reaction conditions for all catalytic reactions. In the presence of Ru-3(CO)(12) as a precatalyst, mixtures of chiral gamma-lactams and 2,3-disubstituted pyrroles are obtained. This combinatorial approach also enables us for the first time to set up rules relating to the effects of specific substituents in the substrates on the outcome of the respective catalytic reaction.
- 出版日期2011-12
