DO A-WAVES HELP PREDICT INTRAVENOUS IMMUNOGLOBULIN RESPONSE IN MULTIFOCAL MOTOR NEUROPATHY WITHOUT BLOCK?

作者：Lange Dale J^*; Nijjar Rajwinder; Voustianiouk Andrei; Seidel Gregory; Panchal Janki; Wang Annabel K

来源：Muscle & Nerve, 2011, 43(4): 537-542.

DOI：10.1002/mus.21914

• A-wave
• conduction block
• F-wave
• IVIg
• late response
• motor neuropathy
• MUNE
• TLI

Introduction: Are there electrophysiological findings that predict response to intravenous immunoglobulin (IVIg) in patients with lower motor neuron (LMN) syndromes without multifocal conduction block (MCB)? Methods: We enrolled 9 patients with LMN syndromes without MCB to receive 18 weeks of IVIg therapy. Response was measured at weeks 2 and 18 using the Appel Amyotrophic Lateral Sclerosis (AALS) score (includes grip and pincer strength measures), ALS Functional Rating Scale (ALSFRS), and electrophysiological measures, including motor unit estimates (MUNEs). Results: No change occurred in AALS or ALSFRS scores posttreatment. Grip/pincer strength increased in 7 patients (P = 0.028) after initial treatment (responders); 2 showed no improvement (non-responders). No electrophysiological measure changed after treatment in either group but MUNEs trended higher (P = 0.055). 'Abnormal A-waves' (complex, repetitive biphasic, or present in multiple nerves) occurred in pretreatment studies more often in responders (P = 0.028). Discussion:'Abnormal A-waves' may signal IVIg-responsive LMN syndromes even if conduction block is absent. Muscle Nerve 43: 537-542, 2011

• 出版日期2011-4