Dual-Enzyme-Loaded Multifunctional Hybrid Nanogel System for Pathological Responsive Ultrasound Imaging and T-2-Weighted Magnetic Resonance Imaging

作者：Wang, Xia; Niu, Dechao; Li, Pei; Wu, Qing; Bo, Xiaowan; Liu, Boji; Bao, Song; Su, Teng; Xu, Huixiong^*; Wang, Qigang

来源：ACS Nano, 2015, 9(6): 5646-5656.

DOI：10.1021/nn5068094

• hybrid nanogels
• pathological responsiveness
• ultrasound imaging
• magnetic resonance imaging

A dual-enzyme-loaded multifunctional hybrid nanogel probe (SPIO@GCS/acryl/biotin-CAT/SOD-gel, or SGC) has been developed for dual-modality pathological responsive ultrasound (US) imaging and enhanced T-2-weighted magnetic resonance (MR) imaging. This probe is composed of functionalized superparamagnetic iron oxide particles, a dual enzyme species (catalase and superoxide dismutase), and a polysaccharide cationic polymer glycol chitosan gel. The dual-modality US/MR imaging capabilities of the hybrid nanogel for responsive US imaging and enhanced T-2-weighted MR imaging have been evaluated both in vitro and in vivo. These results show that the hybrid nanogel SGC can exhibit efficient dual-enzyme biocatalysis with pathological species for responsive US imaging. SEC also demonstrates increased accumulation in acidic environments for enhanced T-2-weighted MR imaging. Further research on these nanogel systems may lead to the development of more efficient US/MR contrast agents.

• 出版日期2015-6
• 单位同济大学; 华东理工大学