Mechanisms regulating oogenesis, folliculogenesis and fertilization in pigs

作者：Kempisty Bartosz^*; Jackowska Marta; Bukowska Dorota; Antosik Pawel; Wozna Magdalena; Piotrowska Hanna; Swierczewska Monika; Jaskowski Jedrzej M

来源：Medycyna Weterynaryjna, 2011, 67(5): 299-303.

• transforming growth factor beta
• oogenesis
• folliculogenesis

This review presents the molecular basis of mechanisms regulating oogenesis and folliculogenesis, as well as the species specificity of these mechanisms and genetic determinants of successful fertilization in pigs.
Oogenesis and folliculogenesis are species-specific processes, although several features are common to all mammals. These features are especially visible in the molecular basis of these processes. The most important genetic factors regulating normal oogenesis and folliculogenesis include the transforming growth factor beta (TGF beta) and several other proteins from the TGF beta family. Several experiments have indicated the influence of this gene's expression on the ability of oocytes to mature, be successfully fertilized, and form a zygote and a blastocyst. However, the regulation of this gene's expression shows a considerable species specificity. Similarly, mechanisms regulating the fertilization process have several features common to all mammalian species, which is especially conspicuous in the structure of genes that are responsible for fertilization. Two important determinants of fertilization ability are oocyte morphology and follicular size.

• 出版日期2011-5