Phytochemical analysis and in vitro evaluation of the biological activity against herpes simplex virus type 1 (HSV-1) of Cedrus libani A. Rich.

作者：Loizzo Monica Rosa^*; Saab Antoine; Tundis Rosa; Statti Giancarlo A; Lampronti Ilaria; Menichini Francesco; Gambari Roberto; Cinatl Jindrich; Doerr Hans Wilhelm

来源：Phytomedicine, 2008, 15(1-2): 79-83.

DOI：10.1016/j.phymed.2007.03.013

• Cedrus libani A. Rich.
• antiviral activity
• herpes simplex virus (HSV-1)
• GC-MS analysis

Cedrus libani are widely used as traditional medicine in Lebanon for treatment of different infection diseases. In the present study we reported the phytochemical composition analyzed by GC-MS of wood essential oil and cones and leaves ethanol extracts. The main components of wood essential oil were himachalol (22.50%), beta-himachalene (21.90%), and alpha-himachalene (10.50%). Leaves ethanol extract was characterized by a high content of germacrene D (29.40%). The same extract obtained from cones essentially contained alpha-pinene (51.0%) and beta-myrcene (13.0%). Moreover, we investigated extracts, essential oil, and identified compounds for their in vitro antiviral activities against herpes simplex virus type 1 (HSV-1). Cytotoxicity was evaluated by MTT assay in Vero cells. Cones and leaves ethanol extracts exhibited an interesting activity with IC50 of 0.50 and 0.66 mg/ml, respectively, at non-cytotoxic concentration. A comparable activity was found when essential oil was tested (IC50 of 0.44 mg/ml).

• 出版日期2008-1
• 单位河北医科大学