Association between serum interleukin-35 levels and severity of acute pancreatitis

作者：Zhang Yi Li; Zhou Xiu Yun; Guo Xian Yang; Tu Jun Wei^*

来源：International Journal of Clinical and Experimental Medicine, 2015, 8(5): 7430-7434.

• Acute pancreatitis
• serum interleukin-35
• biomarker

Inflammatory cytokines have been reported to be associated with pathogenesis of acute pancreatitis. The aim of this study was to measure the serum IL-35 levels in patients with acute pancreatitis and analyze the relationship between IL-35 levels and the disease severity. Thirty-two patients with acute pancreatitis and 32 healthy control subjects were included into the study. The serum levels of IL-35 were measured by enzyme-linked immunosorbent assay upon admission and the following seven days. The relationships with severity and etiology during the clinical course were analyzed. Serum IL-35 levels in patients with acute pancreatitis at the time of admission (5.25 +/- 0.37 ng/mL) were significantly higher than those in healthy controls (1.93 +/- 0.16 ng/mL, P<0.001). Moreover, serum IL-35 levels in patients with severe attacks (7.15 +/- 0.48 ng/mL) were significantly higher than those with moderately severe attacks (5.14 +/- 0.49 ng/mL, P=0.01) and mild attacks (3.69 +/- 0.53 ng/mL, P<0.001). However, there was no significant difference of serum IL-35 levels among patients with acute pancreatitis due of alcohol, gallstone and idiopathy. In addition, the peak serum concentrations of IL-35 were on day 1 after admission. Our results demonstrate that increased serum IL-35 levels may be related to the inflammatory response in patients with acute pancreatitis, suggesting that IL-35 may be used for a potential biomarker of acute pancreatitis.

• 出版日期2015
• 单位温州医科大学