Diastereoselective Synthesis of Symmetrical and Unsymmetrical Tetrahydropyridines Catalyzed by Bi(III) Immobilized on Triazine Dendrimer Stabilized Magnetic Nanoparticles

作者：Asadi Beheshteh; Landarani Isfahani Amir; Mohammadpoor Baltork Iraj^*; Tangestaninejad Shahram; Moghadam Majid; Mirkhani Valiollah; Rudbari Hadi Amiri

来源：ACS Combinatorial Science, 2017, 19(6): 356-364.

DOI：10.1021/acscombsci.6b00180

• Fe3O4 NPs
• triazine dendritic polymer
• tetrahydropyridine
• diastereoselective
• multicomponent reactions (MCRs)

Unsymmetrical 1,2,5,6-tetrahydropyridine-3-carboxylates were obtained for the first time from a five-component Fe3O4@TDSN-Bi(III)-catalyzed reaction of aryl aldehydes, aryl amines, and ethyl acetoacetate. This magnetically separable catalyst enabled the selective incorporation of two different aryl amines or two different aryl aldehydes into the product, and provided excellent yields, short reaction times, mild reaction conditions, satisfactory catalyst recyclability, and low catalyst loading.

• 出版日期2017-6