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摘要
A novel methodology for the synthesis of tetracyclic benzo-pyridonaphthyridines, forming a C-C and a C-N bond in concentrated sulfuric acid at 70 degrees C in a one-pot is reported. The key substrates (9a-m) are prepared by reacting 2-chloro-6-(4-fluorophenyl)-4-methylnicotinenitrile (7) with various anilines followed by dimethylformamide dimethylacetal. The domino reaction is initiated by the protonation of the beta-carbon of the enamine group in 9a-m and terminated by the elimination of dimethylamine.
- 出版日期2013-4-10
