A Gene Signature Predictive for Outcome in Advanced Ovarian Cancer Identifies a Survival Factor: Microfibril-Associated Glycoprotein 2

作者：Mok Samuel C; Bonome Tomas; Vathipadiekal Vinod; Bell Aaron; Johnson Michael E; Wong Kwong kwok; Park Dong Choon; Hao Ke; Yip Daniel K P; Donninger Howard; Ozbun Laurent; Samimi Goli; Brady John; Randonovich Mike; Pise Masison Cindy A; Barrett J Carl; Wong Wing H; Welch William R; Berkowitz Ross S; Birrer Michael J^*

来源：Cancer Cell, 2009, 16(6): 521-532.

DOI：10.1016/j.ccr.2009.10.018

Advanced stage papillary serous tumors of the ovary are responsible for the majority of ovarian cancer deaths, yet the molecular determinants modulating patient survival are poorly characterized. Here, we identify and validate a prognostic gene expression signature correlating with survival in a series of microdissected serous ovarian tumors. Independent evaluation confirmed the association of a prognostic gene microfibril-associated glycoprotein 2 (MAGP2) with poor prognosis, whereas in vitro mechanistic analyses demonstrated its ability to prolong tumor cell survival and stimulate endothelial cell motility and survival via the alpha(V)beta(3) integrin receptor. Increased MAGP2 expression correlated with microvessel density suggesting a proangiogenic role in vivo. Thus, MAGP2 may serve as a survival-associated target.

• 出版日期2009-12-8