A meta analysis of the efficacy of Saccharomyces boulardii in children with acute diarrhea

作者：Pan Jun; Hu Jiang; Qi Xusheng; Tu Ziliang^*

来源：African Journal of Pharmacy and Pharmacology, 2012, 6(21): 1508-1514.

DOI：10.5897/AJPP11.880

• Saccharomyces boulardii
• acute diarrhoea
• meta-analysis

This study was performed to evaluate the efficacy of Saccharomyces boulardii in treating children with acute diarrhoea. Medicinal databases and review articles were screened with prespecified criteria for randomized controlled trials that reported the effects of S. boulardii and other antidiarrhoeal drugs in treating children with acute diarrhoea. The quality of the study was critically evaluated. A total of 678 articles were found and 8 articles were finally included. Heterogeneity test: Diarrhoea duration analysis (Qstatistic=33.58, p<0.0001, I-2=79%), stool frequency on day 3 analysis (Qstatistic=4.53, p=0.10, I-2=56%), stool frequency on day 4 analysis (Qstatistic=0, p=1.00, I-2=0%) and stool frequency on day 7 analysis (Q statistic=0.18, p=0.68, I-2=0%). The results of meta-analysis showed that when compared with the control group, S. boulardii was more effective in diarrhoea duration (MD=-0.92, 95% CI: -1.32 to -0.52), stool frequency on day 3 (MD=-1.92, 95% CI: -1.63 to -0.95), day 4 (MD=-0.51, 95% CI: -0.89 to -0.33) and day 7 (MD=-0.44, 95% CI: -0.72 to -0.16), respectively. The evidence currently available shows that S. boulardii treatment is used for children with acute diarrhoea.

• 出版日期2012-6
• 单位湖北医药学院