New phenethylamine derivatives from Arenibacter nanhaiticus sp nov NH36AT and their antimicrobial activity

作者：Chen, Yanping; Tang, Jinshan^*; Tang, Xixiang; Wang, Chuanxi; Lian, Yunyang; Shao, Zongze; Yao, Xinsheng; Gao, Hao

来源：Journal of Antibiotics, 2013, 66(11): 655-661.

DOI：10.1038/ja.2013.65

• absolute configurations
• antimicrobial activity
• enantiomers
• Marfey's method
• phenethylamine derivatives

Five new phenethylamine (PEA) derivatives (1-5) were isolated from the strain of Arenibacter nanhaiticus sp. nov. NH36A(T) derived from the marine sediment of the South China Sea by bioassay-guided fractionation. Their structures were elucidated by spectroscopic methods including UV, IR, HR-MS and NMR. Interestingly, compounds 1-4 existed as enantiomers, which were resolved by chiral liquid chromatography. The resolved configuration of each enantiomer was assigned by the Marfey's method. Of these compounds, 5 showed weak antimicrobial activity against Staphylococcus aureus and Bacillus subtilis with MIC values of 0.50 and 0.25 mg ml(-1), respectively.

• 出版日期2013-11
• 单位暨南大学; 福建省微生物研究所; 国家海洋局第三海洋研究所