The Relationship Between Vitamin E Plasma and BAL Concentrations, SOD Activity and Ventilatory Support Measures in Critically Ill Patients

作者：Ziaie Shadi; Jamaati Hamidreza; Hajimahmoodi Mannan; Hashemian Seyyed Mohammadreza; Fahimi Fanak; Farzanegan Behrooz; Moghaddam Ghazaleh; Radmand Golnar; Vandani Behzad; Nadji Seyed Alireza; Mousavi Sarah; Hamishehkar Hadi; Mojtahedzadeh Mojtaba^*

来源：Iranian Journal of Pharmaceutical Research, 2011, 10(4): 953-960.

• Vitamin E
• SOD
• Antioxidant
• Oxidative stress
• Mechanical ventilation

Vitamin E is a potent reactive oxygen metabolites (ROM) scavenger. It is a lipid-soluble vitamin and its main Function is to protect polyunsaturated fatty acids against oxidative stress.
Twenty-five mechanically ventilated Intensive Care Unit (ICU) adult patients participated in a prospective randomized clinical trial receiving either placebo (10 patients) or 3 IM doses (1000 I U each) of vitamin E (15 patients). We determined plasma and bronchoalveolar lavage (BAL) fluid concentrations of vitamin E and superoxide dismutase (SOD).
Among these 25 patients, there were 14 men and 11 women, aged 63.16 +/- 15.48 years (mean +/- SD; range = 33 to 87 years). Vitamin E supplementation resulted in significant differences in plasma and BAL vitamin E concentrations between the two groups (p-value = 0.01, 0.01), decrease in SOD activities (not differ significantly in plasma (p-value = 0.23)), but with significant differences in BA L (p-value = 0.016) and progressive reduction in Acute Physiology and Chronic Health Evaluation II (APACHE II) (p-value = 0.52) and Sequential Organ Failure Assessment (SOFA) (p-value = 0.008) score in vitamin E group.
From the results of this study, it seems that supplementation of vitamin E as a potent antioxidant, along with other supportive measures, can be beneficial in decreasing SOD total activity, ROM production and risk of organ failure in critically ill patients.

• 出版日期2011