Antibacterial, Cytotoxic Studies and Characterization of Some Newly Synthesized Symmetrical N-3, N-3 %26apos;-Bis(disubstituted) isophthalyl-bis(thioureas) and Their Cu(II) and Ni(II) Complexes

作者：Jamil Muhammad; Zubair Muhammad^*; Farid Muhammad Asim; Rashid Umer; Rasool Nasir; Islam Saiful

来源：Journal of Chemistry, 2013, 2013: 789743.

DOI：10.1155/2013/789743

A series of some novel N-3, N-3%26apos; -bis(disubstituted) isophthalyl-bis(thioureas) compounds with general formula [ C 6 H 4 center dot {CONHCSNHR} 2], where R = 2-ClC6H4S(L-1), 3,5-(Cl)(2) C-6 H-3 (L-2), 2,4-(Cl)(2)C6H3 (L-3), 2,5-(Cl)(2)C6H3 (L-4), and 2-NH2C6H4 (L-5),and their Cu(II) and Ni(II) complexes (C-1 -C-10) have been synthesized. These compounds (L-1 -L-5) and their metal(II) complexes (C-1 -C-10) have been characterized by elemental analysis, infrared spectroscopy, 1 H NMR and 13 C NMR spectroscopy, magnetic moments, and electronic spectral measurements. The ligands are coordinated to metal atom in a bidentate pattern producing a neutral complex of the type [ML] 2. These compounds (L-1 -L-5) and their metal(II) complexes (C-1 -C-10) were also screened for their antibacterial and cytotoxic activities.

• 出版日期2013