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摘要
Purpose: Grading of disease activity in patients with atopic keratoconjunctivitis (AKC) is limited by intra- and inter-observer variability. The aim of this study was to identify angiographic parameters to help evaluate inflammation and disease activity.Methods: In 12 patients (4 with active, 2 with inactive AKC, and 6 controls), disease activity were assessed using a validated biomicroscopic grading scale. Imaging of upper tarsal conjunctiva was undertaken using color photography, fluorescein (FA) and indocyanine green angiography (ICGA).Results: Extravascular ICG leakage only occurred in patients with active disease (mean 84.6 28.8 s) except in one patient with inactive disease but only after 6 min. Transepithelial leakage of fluorescein occurred in all patients with active AKC (mean 63.5 +/- 17.8 s) but not in patients with inactive disease or controls.Conclusions: Conjunctival transepithelial leakage of fluorescein and extravascular interstitial accumulation of ICG may be useful markers of disease activity patients in AKC.
- 出版日期2018
