Mitosis: Short-Circuiting Spindle Checkpoint Signaling

作者:Luo Xuelian*; Yu Hongtao
来源:Current Biology, 2012, 22(4): R128-R130.
DOI:10.1016/j.cub.2012.01.018

摘要

The spindle checkpoint forms an intricate signaling circuit to sense unattached kinetochores, to inhibit the anaphase-promoting complex/cyclosome (APC/C), and to delay anaphase onset. Using clever genetic experiments in the budding yeast, Lau and Murray define the endpoint of checkpoint signaling and provide key mechanistic insights into checkpoint inhibition of APC/C.