DLX1, a binding protein of beta-catenin, promoted the growth and migration of prostate cancer cells

作者：Liang, Ming; Sun, Yan; Yang, Huai-Liang; Zhang, Bin; Wen, Ji; Shi, Ben-Kang^*

来源：Experimental Cell Research, 2018, 363(1): 26-32.

DOI：10.1016/j.yexcr.2018.01.007

• DLX1
• Beta-catenin/TCF signaling
• Prostate cancer
• Cell growth and migration

Several studies have indicated the involvement of DLX1 in the progression of prostate cancer. However, the functions of DLX1 in the prostate cancer and the underlying molecular mechanism remains largely unknown. In this study, we have shown that DLX1 was up-regulated in the prostate clinical samples. DLX1 promoted the growth, migration and colony formation of prostate cancer cells by activating beta-catenin/TCF signaling. DLX1 interacted with beta-catenin and enhanced the interaction between beta-catenin and TCF4. Taken together, this study demonstrated that DLX1 exerted the oncogenic roles on the prostate cancer by activating beta-catenin/TCF signaling.

• 出版日期2018-2-15
• 单位山东大学; 山东中医药大学