A dual-response fluorescent probe for Zn2+ and Al3+ detection in aqueous media: pH-dependent selectivity and practical application

作者：Tang, Yunqiang; Sun, Jinguo; Yin, Bingzhu^*

来源：Analytica Chimica Acta, 2016, 942: 104-111.

DOI：10.1016/j.aca.2016.08.048

• Schiff base-type fluorescent probe
• Zn2+
• Al3+
• pH dependent selectivity
• Bioimaging
• Drug sample

A Schiff base-type fluorescent probe (1) consist of 2-hydroxynaphthaldehyde and glutamide moieties has been designed and synthesized for detection Zn2+ and Al3+. The probe shows pH dependent dualselectivity for Zn2+ and Al3+ in Tris-HCl buffer, viz. that can selectively recognized Zn2+ at pH 7.4 and Al3+ at pH 6.0, respectively. From Job's plots and MS data, the stoichiometric ratios of the probe with Zn2+ and Al3+ appeared to be 1:1 and 2:1, respectively. The probe can detect as low as 5.5 x 10(-8) M-1 Zn2+ and 1.27 x 10(-7) M-1 Al3+, whereas respective association constants are 4.27 x 10(4) M-1 and 3.50 x 109 M-1. Furthermore, it is also confirmed that the probe has good cell-permeability and could thus be used to selectively sense intracellular Zn2+ and Al3+ by bioimaging in different pH environment. Finally the probe has been used successfully for determination of the analytes in real drug samples.

• 出版日期2016-10-26
• 单位延边大学