A new multicomponent reaction for the synthesis of pyridines via cycloaddition of azadienes and ketenimines

作者：Coffinier Didier; El Kaim Laurent^*; Grimaud Laurence; Ruijter Eelco; Orru Romano V A

来源：Tetrahedron Letters, 2011, 52(23): 3023-3025.

DOI：10.1016/j.tetlet.2011.04.007

• Isocyanides
• Nef
• Perkow
• Azadiene
• [4+2] Cycloaddition
• Pyridine

The ketenimines resulting from a Nef isocyanide/Perkow sequence react with 1-azadienes to form pyridines or pyrimidines depending on their substitution pattern. The reaction is most efficient with ester-substituted ketenimines which leads to pyridines after elimination of the phosphate group.

• 出版日期2011-6-8